Has there been trials on people?

Yes there has, with great results.  For more information, see our Studies page.

What is Sibelius Sage™

Sibelius sage™ is a specifically grown and harvested extract of sage (Salvia officianalis) that has been tested and clinically trialed for its effects on cognitive processes.  For more information, see our page What is Sibelius Sage™?

Where and how is it grown?

Sibelius sage™ is grown just outside Hampshire in the UK on our farm which is dedicated just to the sage to prevent risk of cross contamination.   The plants are managed under Good Agricultural Practic standards and is harvested between November and March each year.

What dose should I take?

Our clinical trial showed that the 333mg input dose (approximately 2.5 g herbal equivalent) of the Sibelius sage™ has the best outcomes.

What is Chronoscreen™ testing?

ChronoscreenTM is a functional assay of biological activity. It is a phenotypic screen giving a whole organism, whole lifespan readout of an ingredient activity on pathways of cellular aging. Any ingredient can be tested using this model to see the effect on aspects of cellular ageing.

Is Sibelius sage™ GRAS?

GRAS or generally regarded as safe is an international standard for food and herbal ingredients governed by the FDA.  It means they consider the material to be safe for human consumption.   Sibelius sage is GRAS.

How does Sibelius sage™ work?

Sage (Salvia officinalis ) has a long history of traditional use in Western Herbal medicine, including for cognitive support.

The mechanism of action has not been fully uncovered at this time, and this is possibly because it affects a number of different pathways that are involved in cognitive function.  However, at this time there are interesting actions that have been uncovered that may help explain the effect in part.

Neurotransmitters are broken down in the body by enzymes. Sage extracts have been shown to inhibit the action of acetylcholinesterase; the enzyme that breaks down the neurotransmitter acetylcholine.  Acetylcholine is found in the brain in areas associated with attention, memory and motivation.

In addition, sage has been shown to possess antioxidant, anti-inflammatory and estrogenic properties. Hormonal imbalance, inflammation and oxidative stress may all contribute to decreased cognitive function.